Publications – United Therapeutics Medical Affairs

The following information is limited to United Therapeutics sponsored studies. Information is not intended to offer recommendations for any administration, indication, dosage, or other use inconsistent with approved prescribing information.

Reasons for Refusing Parenteral Therapy: A Qualitative Study of Patients with Pulmonary Arterial Hypertention

Pulmonary Hypertension Due to Interstitial Lung Disease or Chronic Obstructive Pulmonary Disease: A Patient Experience Study of Symptoms and Their Impact on Quality of Life

Long-term follow-up of a Phase III Study of ch14.18 (Dinutuximab) + Cytokine Immunotherapy in Children with High-risk Neuroblastoma: COG Study ANBL0032

Inhaled Treprostinil and Forced Vital Capacity Change in Patients with Interstitial Lung Disease and Associated Pulmonary Hypertension: A post-hoc analysis of the INCREASE study

Improving Communication Between Healthcare Providers and Pulmonary Arterial Hypertension Patients: A Survey of Patient Preferences

Health Outcomes in Pulmonary Arterial Hypertension Patients with COVID-19: A Real-World Analysis

Efficacy of inhaled treprostinil on multiple disease progression events in patients with pulmonary hypertension due to parenchymal lung disease in the INCREASE trial

Economic Burden of Patients with Pulmonary Arterial Hypertension Prior to Initiation of Treprostinil: A Retrospective Analysis of US Claims

Development of the Pulmonary Hypertension Functional Classification Self-Report: A Patient Version Adapted from the World Health Organization Functional Classification Measure

Combination Therapy in Pulmonary Arterial Hypertension — Targeting the Nitric Oxide and Prostacyclin Pathways

Clinical Improvement in Patients Treated with Oral Treprostinil: A Post Hoc Analysis of the FREEDOM-EV Study

Clinical Improvement in Patients Treated with Inhaled Treprostinil: A Post Hoc Analysis of the INCREASE Study

An Expert Panel Delphi Consensus Statement on Appropriate Patient Selection and Management of Adverse Events in Patients Receiving Oral Treprostinil forthe Treatment of Pulmonary Arterial Hypertension

A multicenter, retrospective study of patients with pulmonary hypertension transitioned from inhaled to oral treprostinil

An Expert Panel Delphi Consensus Statement on Patient Selection and Management for Transitioning Between Oral and Inhaled Treprostinil

The Impact of Hemodynamic Parameters on Inhaled Treprostinil Treatment Response –A Subgroup Analysis from the INCREASE Trial

Dose-response Analysis of Inhaled Treprostinil in Pulmonary Hypertension Associated with Interstitial Lung Disease and Its Effects on Clinical Worsening

Comparison of effects of inhaled treprostinil on lung function in patients with interstitial lung disease associated pulmonary hypertension and pulmonary arterial hypertension

Analysis of Real-world Pharmacovigilance Data of Parenteral Treprostinil for Pulmonary Arterial Hypertension (PAH) in the Pediatric Versus Adult Population

Interim Analysis from the ADAPT Registry: Real-World Patient Reported Outcomes Using SF-12 and Emphasis-10 in Patients Receiving Oral Treprostinil

Outcomes and costs associated with oral treprostinil and selexipag one-year into treatment: a U.S. claims database analysis in patients with pulmonary arterial hypertension

Screening Strategies for Pulmonary Hypertension (PH) in Interstitial Lung Disease (ILD): A Multidisciplinary Delphi Study

BREEZE: Clinical Outcomes and Pharmacokinetics of Treprostinil Inhalation Powder (Tyvaso DPI)

Burden of Illness in Patients with Pulmonary Hypertension due to Interstitial Lung Disease: A Real-World Analysis using US Claims Data

Healthcare Resource Utilization and Treatment Patterns Before and After Initiation of Inhaled Treprostinil

Inhaled Treprostinil in Pulmonary Hypertension due to Interstitial Lung Disease

Advance Outcomes – a Phase 3, Randomized, Double-blind, Placebo-controlled study to evaluate the efficacy and safety of ralinepag to improve treatment outcomes in subjects with pulmonary arterial hypertension

Design of ADVANCE CAPACITY: Effects of ralinepag on exercise capacity measured by cardiopulmonary exercise testing.

Real-world transitions from inhaled, parenteral, and oral prostacyclin class agents to oral treprostinil: Interim data from the ADAPT registry

Interim Results from EXPEDITE: A Study of Parenteral Treprostinil Induction Followed by Oral Treprostinil Optimization in Subjects with Pulmonary Arterial Hypertension

Interim data from the ADAPT registry: Real-world tolerability and management of adverse events in patients receiving oral treprostinil

Pharmacokinetics of Oral Treprostinil in Children with Pulmonary Arterial Hypertension

Contemporary dosing characteristics of oral treprostinil in real world clinical practice in patients with pulmonary arterial hypertension

Understanding the Psychological Mindset of People with PAH

Low Utilization of Prostacyclin Therapy Prior to Death Among Medicare Patients With Pulmonary Arterial Hypertension

Development of the Pulmonary Hypertension Functional Class Self-Report (PH-FC-SR)

The Impact of Inhaled Treprostinil on Patient Lung Function – Results from the INCREASE Study

Reasons for Refusing Parenteral Therapy: A Qualitative Study of Patients with Pulmonary Arterial Hypertension

Implantable System for Treprostinil: A Real-World Patient Experience Study

Medication Adherence and Healthcare Costs among Patients Diagnosed with Pulmonary Arterial Hypertension Treated with Oral Prostacyclin-class Therapies: A Retrospective Cohort Study

Baseline Risk Evaluation Predicts Likelihood of Clinical Worsening: A Sample Size Re-analysis from Freedom-EV

Treatment with Oral Treprostinil Improves Hemodynamics in PAH: FREEDOM-EV

Do Plasma Metabolomic Profiles Differentiate Responders from Nonresponders to Oral Treprostinil? Results from the FREEDOM Phase 3 Clinical Development Program

Novel dose-response analyses of treprostinil in pulmonary arterial hypertension and its effects on 6-minute walk distance and hospitalizations

The Impact of Stratification by Baseline Pulmonary Arterial Hypertension Risk Score – Analysis from the FREEDOM-EV Study

Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial

Inhaled Treprostinil in Interstitial Lung Disease Associated Pulmonary Hypertension: The INCREASE Study

An Analysis of FREEDOM-EV Using the French Noninvasive and REVEAL 2.0 Risk Stratification Criteria

Totally Implantable IV Treprostinil Therapy in Pulmonary Hypertension Assessment of the Implantation Procedure

Long-term results of the DelIVery for Pulmonary Arterial Hypertension trial

Treprostinil Administered to Treat Pulmonary Arterial Hypertension Using a Fully Implantable Programmable Intravascular Delivery System: Results of the DelIVery for PAH Trial

Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension: A Double-Blind, Placebo-Controlled Study

Long term oral treprostinil use in prospective studies: dosing, tolerability, and pharmacokinetics – substudy to evaluate pharmacokinetics and adverse events in patients transitioning from twice daily to three times daily dosing

The Role of Noninvasive Endpoints in Predicting Long-Term Outcomes in Pulmonary Arterial Hypertension

Effect of esuberaprost on morbidity and mortality in World Health Organization (WHO) Functional Class (FC) III and IV Patients with pulmonary arterial hypertension (PAH): Results from the randomized, double-blind, placebo-controlled Phase 3 Trial- Beraprost-314d Added to Tyvaso (BEAT)

Survival and drug persistence in patients with pulmonary arterial hypertension receiving inhaled treprostinil at doses greater than 54 mcg (9 breaths) 4 times daily

Real-world characteristics of patients initiating oral treprostinil in the ADAPT registry: interim baseline characteristics

Treatment benefits associated with open label oral treprostinil after clinical worsening in the phase 3 FREEDOM-EV study for the treatment of pulmonary arterial hypertension

Dose-response relationship of oral treprostinil for secondary endpoints in the FREEDOM-EV study

A phase 1, single-center, open-label, dose-rising clinical trial to evaluate the pharmacokinetics, safety and tolerability of Treprostinil Inhalation Powder (TreT) in healthy normal volunteers

An open-label, clinical study to evaluate the safety and tolerability of Treprostinil Inhalation Powder (TreT) in patients with pulmonary arterial hypertension (BREEZE Study)

Treatment with Oral Treprostinil Delays Disease Progression in Participants with Pulmonary Arterial Hypertension – Results from the FREEDOM-EV Study

A phase 1, single-center, open-label, dose-rising clinical trial to evaluate the pharmacokinetics, safety and tolerability of Treprostinil Inhalation Powder (TreT) in healthy normal volunteers

Cytokine Profile and Association with Toxicities and Outcome of High-Risk Neuroblastoma Treated with Dinutuximab Immunotherapy on COG ANBL0931

Phase II Trial of Irinotecan/Temozolomide with Dinutuximab/GMCSF (I/T/DIN/GMCSF) in Relapsed/Refractory Neuroblastoma: A Report from The Children’s Oncology Group (COG)

Dinutuximab binds specifically to Disialoganglioside-2

Borg Dyspnea Score Adjusted Six Minute Walk Distance in Pulmonary Arterial Hypertension Clinical Trials

Treatment with Oral Treprostinil is Associated with Improved Survival in Pulmonary Arterial Hypertension Participants from the FREEDOM-EV Study

Treatment with oral treprostinil significantly delays time to clinical worsening in patients with pulmonary arterial hypertension – results from the phase 3, randomized, double-blind, placebo-controlled FREEDOM-EV study

Identifying patients with pulmonary arterial hypertension (PAH) using administrative claims algorithms

Early versus late initiation of treatment with prostacyclin-class therapy in patients with Pulmonary Arterial Hypertension (PAH)

A real-world health insurance claims analysis of oral prostacyclin class therapy utilization and outcomes

Risk stratification Using Noninvasive Parameters: A post hoc analysis of the TRIUMPH and FREEDOM-C2 studies

The economic burden of pulmonary hypertension among patients with chronic obstructive pulmonary disease and interstitial lung disease

Real-World Dosing Characteristics of Parenteral Treprostinil

Risk Scores and Risk-based Stratification of Clinical Worsening Events in PAH Patients Treated with Oral Treprostinil in FREEDOM-EV

Treatment with prostacyclins delays and reduces hospital readmissions among PAH patients

88P Feasibility of outpatient dinutuximab (D) and irinotecan (I) for second-line treatment of relapsed or refractory small cell lung cancer (RR SCLC): Part 1 of an open-label, randomized, phase 2/3 study

Transition to Oral Treprostinil from Parenteral or Inhaled Treprostinil or as Add-on Therapy in Pediatric Subjects with Pulmonary Arterial Hypertension

A Two-Part, Open-Label, Randomized, Phase 2/3 Study of Dinutuximab and Irinotecan versus Irinotecan for Second-Line Treatment of Subjects with Relapsed or Refractory Small Cell Lung Cancer

The Effect of Treprostinil Dose on Time to All Cause and Pulmonary Arterial Hypertension-Related Hospitalizations

The relationship between non-invasive endpoints and long-term outcomes in pulmonary arterial hypertension: six-minute walk, functional class and brain natriuretic peptide

Predicting adherence to oral treprostinil in patients with pulmonary arterial hypertension

Treatment with prostacyclins reduces hospital readmissions among patients with pulmonary arterial hypertension

The impact of delayed treatment on 6-minute walk distance test in patients with pulmonary arterial hypertension: a meta-analysis

Combination therapy reduces hospitalizations in patients with pulmonary arterial hypertension

Novel analysis of treprostinil dose-response relationship using weight-normalized dosing

A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Subjects with Pulmonary Hypertension Due to Parenchymal Lung Disease (Study RIN-PH-201)

Increasing treprostinil dose reduces annual hospitalization rates and consequent costs in patients with pulmonary arterial hypertension

Stability of treprostinil with diluents and medications

Pharmacokinetics of oral treprostinil in children with pulmonary arterial hypertension

Dosing characteristics of oral treprostinil in real-world clinical practice